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Aripiprazole is a wide-used antipsychotic drug with therapeutic effects on both positive and negative symptoms of schizophrenia, and reduced side-effects. Although aripiprazole was developed as a dopamine D 2 receptor D 2 R partial agonist, all other D 2 R partial agonists that aimed to mimic aripiprazole failed to exert therapeutic effects in clinic. Rats were injected once with aripiprazole 0. This study further indicated that, by comparison with bifeprunox, the unique pharmacological profile of aripiprazole may be attributed to the relatively lower intrinsic activity at D 2 R. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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She was cited as the most awarded female artist of all time by Guinness World Records and remains one of the best-selling music artists of all time with million records sold worldwide. Houston released seven studio albums and two soundtrack albums, all of which have been certified diamond, multi-platinum, platinum, or gold by the Recording Industry Association of America RIAA. Houston began singing in church as a child and became a background vocalist while in high school. With the guidance of Arista Records chairman Clive Davis , she signed to the label at the age of Her first two studio albums, Whitney Houston and Whitney , both reached number one on the Billboard in the United States. Houston made her screen acting debut in the romantic thriller film The Bodyguard She recorded six songs for the film's soundtrack , including " I Will Always Love You ", which received the Grammy Award for Record of the Year and became the best-selling single by a woman in music history.
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